"Human bodies are designed for regular physical activity. The sedentary nature of much of modern life probably plays a significant role in the epidemic incidence of depression today. Many studies show that depressed patients who stick to a regimen of aerobic exercise improve as much as those treated with medication."
"Another very common use, in all cultures, of psychoactive substances is to give people transcendent experiences. To allow them to transcend their human and ego boundaries to feel greater contact with the supernatural, or with the spiritual, or with the divine, however they phrase it in their terms."
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Source: Andrew Weil, M.D. (2010). “You Can't Afford to Get Sick: Your Guide to Optimum Health and Health Care”, p.8, Penguin
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