"It is what we know already that often prevents us from learning."
"Laplace considers astronomy a science of observation, because we can only observe the movements of the planets; we cannot reach them, indeed, to alter their course and to experiment with them. "On earth," said Laplace, "we make phenomena vary by experiments; in the sky, we carefully define all the phenomena presented to us by celestial motion." Certain physicians call medicine a science of observations, because they wrongly think that experimentation is inapplicable to it."
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Source: Claude Bernard (2012). “An Introduction to the Study of Experimental Medicine”, p.47, Courier Corporation
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