"It is what we know already that often prevents us from learning."
"Mediocre men often have the most acquired knowledge. It is in the darker. It is in the darker regions of science that great men are recognized; they are marked by ideas which light up phenomena hitherto obscure and carry science forward."
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Source: Claude Bernard (2012). “An Introduction to the Study of Experimental Medicine”, p.70, Courier Corporation
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"The experimenter who does not know what he is looking for will not understand what he finds."
"When we meet a fact which contradicts a prevailing theory, we must accept the fact and abandon the theory, even when the theory is supported by great names and generally accepted."
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"Men who have excessive faith in their theories or ideas are not only ill prepared for making discoveries; they also make very poor observations. Of necessity, they observe with a preconceived idea, and when they devise an experiment, they can see, in its results,only a confirmation of their theory. In this way they distort observation and often neglect very important facts because they do not further their aim."