"The great tragedy of science - the slaying of a beautiful hypothesis by an ugly fact."
"Science seems to me to teach in the highest and strongest manner the great truth which is embodied in the Christian conception of entire surrender to the will of God. Sit down before fact as a little child, be prepared to give up every preconceived notion, follow humbly wherever and to whatever abysses nature leads, or you shall learn nothing. I have only begun to learn content and peace of mind since I have resolved at all risks to do this."
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Source: Letter to Charles Kingsley, mathcs.clarku.edu. September 23, 1860.
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